THE CHEMICAL NATURE OF GRAMICIDIN AND TYROCIDINE
نویسندگان
چکیده
منابع مشابه
The Chemical Nature of Gramicidin and Tyrocidine
The work reported here is a continuation of earlier investigations on the chemical nature of two bactericidal substances, gramicidin and tyrocidine, isolated from cultures of Bacillus brevis (1-3). Christensen, Edwards, and Piersma are at the same time submitting a report of work which has been carried on independently in their laboratory (4). Tyrocidine hydrochloride and gramicidin are both co...
متن کاملTHE OCCURRENCE OF d-AMINO ACIDS IN GRAMICIDIN AND TYROCIDINE
Amino acids having a dextro configuration have been found in natural material from two sources.’ Jacobs and Craig obtained d-proline from ergotinine (4) and later other ergot alkaloids, and IvAnovics and Bruckner found d( -)-glutamic acid as the principal constituent of the P-antigen of Bacillus anthracis and other microorganisms of the related Bacillus mesentericus-subtilis group (5). Inasmuch...
متن کاملThe Effect of Gramicidin and Tyrocidine on Bacterial Metabolism
Most of the common antiseptics, heavy metals, chlorine compounds, phenolic compounds, detergents, etc., exert an inhibitory effect upon the metabolism of the susceptible microbial species. There are, however, a few substances which, although possessing marked bacteriostatic activity, do not appear to interrupt respiratory processes. This is particularly true of the sulfona,mides. Cultures of Ba...
متن کاملPantetheine-linked peptide intermediates in gramicidin S and tyrocidine biosynthesis.
To study the function of pantetheine in gramicidin S and tyrocidine biosynthesis, pepsin digests of the polymerizing enzymes, of which only the heavy ones contain pantetheine, were analyzed. The digests of gramicidin S enzymes charged with either [(14)C]proline or with D-phenylalanyl-[(14)C]proline, were analyzed by thin-layer chromatography; only the dipeptide showed a derivative associated wi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1941
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)72832-9